Variable |
Input/ Assumption |
Base Case Patient |
62 year old man, NSCLC confirmed and fit |
Diagnostic accuracy | |
Sensitivity of FDG PET if CT |
86% with 95% CI (0.79, 0.91) - (HTBS) |
Specificity of FDG PET if CT |
90% with 95% CI (0.87, 0.93) - (HTBS) |
Sensitivity of FDG PET if CT |
92% with 95% CI (0.87, 0.95) - (HTBS) |
Specificity of FDG PET if CT |
76% with 95% CI (0.69, 0.82) - (HTBS) |
Sensitivity of FDG PET detecting __________distant Metastasis__________ |
93% - (NICE) |
Sensitivity of Mediastinoscopy |
72% - (Dietlein) |
Specificity of Mediastinoscopy |
100% - (Dietlein) |
Mortality | |
CT and PET mortality |
0% - (Dietlein) |
Surgery mortality |
3.7% - (Dietlein) |
Mediastinoscopy mortality |
0.5% - (Dietlein) |
Life Expectancy | |
Life expectancy after surgery |
N0/1; M0: 4.5 years N2/3; M0: 1.8 years M1: 0.5 years ___________________(Dietlein)___________________ |
Life expectancy after palliation |
N0/1; M0: 2.6 years N2/3; M0: 1.8 years M1: 0.5 years ___________________(Dietlein)___________________ |
Other Assumptions | |
Percentage of patients straight to |
58% (Dietlein) |
Complication rate of surgery |
37.5% (Own estimate based on Viney) |
Probability patients upstage during |
10% (HTBS) |
14
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