Economic Evaluation of Positron Emission Tomography (PET) in Non Small Cell Lung Cancer (NSCLC), CHERE Working Paper 2007/6

Variable

Input/ Assumption

Base Case Patient

62 year old man, NSCLC confirmed and fit
for surgery or non surgical treatment.
___________________(Dietlein)___________________

Diagnostic accuracy

Sensitivity of FDG PET if CT
negative

86% with 95% CI (0.79, 0.91) - (HTBS)

Specificity of FDG PET if CT
negative

90% with 95% CI (0.87, 0.93) - (HTBS)

Sensitivity of FDG PET if CT
positive

92% with 95% CI (0.87, 0.95) - (HTBS)

Specificity of FDG PET if CT
_______________positive_______________

76% with 95% CI (0.69, 0.82) - (HTBS)

Sensitivity of FDG PET detecting

__________distant Metastasis__________

93% - (NICE)

Sensitivity of Mediastinoscopy

72% - (Dietlein)

Specificity of Mediastinoscopy

100% - (Dietlein)

Mortality

CT and PET mortality

0% - (Dietlein)

Surgery mortality

3.7% - (Dietlein)

Mediastinoscopy mortality

0.5% - (Dietlein)

Life Expectancy

Life expectancy after surgery

N0/1; M0: 4.5 years

N2/3; M0: 1.8 years

M1:       0.5 years

___________________(Dietlein)___________________

Life expectancy after palliation

N0/1; M0: 2.6 years

N2/3; M0: 1.8 years

M1:       0.5 years

___________________(Dietlein)___________________

Other Assumptions

Percentage of patients straight to
_______________surgery_______________

58% (Dietlein)

Complication rate of surgery

37.5% (Own estimate based on Viney)

Probability patients upstage during
thoractomy from N0/1 to N2/3

10% (HTBS)