Provided by Cognitive Sciences ePrint Archive
I ιdian
RACING.and ELECTROPHYSIOLOGY www.ipej.org 6
Journal
Original Article
Short- and long-term experience in pulmonary vein
segmental ostial ablation for paroxysmal atrial fibrillation*
*English version of "Langzeit-Ergebnisse der ostialen Pulmonalvenenisolation bei
paroxysmalem Vorhofflimmern", J Kardiol 2005; 12: 231-6, "Copyright 2005 by Krause &
Pachernegg, Austria"; published with permission from publisher. Web link to the original
German version (pdf): www.kup.at/kup/pdf/5370.pdf
Purerfellner H., Aichinger J., Martinek M., Nesser H.J., Janssen J.t
Public Hospital Elisabethinen, Academic Teaching Hospital, Cardiological Department, Linz,
Austria
^Medtronic Inc. , Bakken Research Center, Maastricht, Holland
Address for correspondence: Helmut Purerfellner, MD, KH der Elisabethinen, II. Interne
AbteilungZKardiologie, Fadingerstr. 1, A-4010 Linz, Austria, Europe. E-mail:
Abstract
Introduction: Segmental ostial pulmonary vein isolation (PVI) is considered a potentially
curative therapeutic approach in the treatment of paroxysmal atrial fibrillation (PAF). There is
only limited data available on the long-term effect of this procedure.
Methods: Patients (Pts) underwent a regular clinical follow up visit at 3, 6 and 24 months after
PVI. Clinical success was classified as complete (i.e. no arrhythmia recurrences, no
antiarrhythmic drug), partial (i.e. no/only few recurrences, on drug) or as a failure (no benefit).
The clinical responder rate (CRR) was determined by combining complete and partial success.
Results: 117 patients (96 male, 21 female), aged 51±11 years (range 25 to 73) underwent a total
of 166 procedures (1.4/patient) in 2-4 pulmonary veins (PV). 115 patients (98%) had AF, 2
patients presented with regular PV atrial tachycardia. ,109/115 patients. exhibited PAF as the
primary arrhythmia (versus persistent AF). A total of 113 patients with PVI in the years 2001 to
2003 were evaluated for their CRR after 6 (3) months. A single intervention was carried out in
63 patients (55.8%), two interventions were performed in 45 patients (39.8%) and three
interventions in 5 patients (4.4%). The clinical response demonstrated a complete success of
52% (59 patients), a partial success of 26% (29 patients) and a failure rate of 22% (25 patients),
leading to a CRR of 78% (88 patients). Ostial PVI in all 4 PVs exhibited a tendency towards
higher curative success rates (54% versus 44% in patients with 3 PVs ablated for the 6 month
follow up). Long-term clinical outcome was evaluated in 39 patients with an ablation attempt at
3 PVs only (excluding the right inferior PV in our early experience) and a mean clinical follow
up of 21±6 months. At this point in time the success rate was 41% (complete, 16 patients) and
21% (partial, 8 patients), respectively, adding up to a CRR of 62% (24 patients). In total, 20
patients (17.1%) had either a single or 2 (3 patients, 2.6%) complications independent of the
number of procedures performed with PV stenosis as the leading cause (7.7%).
Indian Pacing and Electrophysiology Journal (ISSN 0972-6292), 6(1): 6-16 (2006)
More intriguing information
1. Solidaristic Wage Bargaining2. Conditions for learning: partnerships for engaging secondary pupils with contemporary art.
3. The name is absent
4. The name is absent
5. The role of statin drugs in combating cardiovascular diseases
6. CONSUMER ACCEPTANCE OF GENETICALLY MODIFIED FOODS
7. Family, social security and social insurance: General remarks and the present discussion in Germany as a case study
8. The name is absent
9. EU Preferential Partners in Search of New Policy Strategies for Agriculture: The Case of Citrus Sector in Trinidad and Tobago
10. Behaviour-based Knowledge Systems: An Epigenetic Path from Behaviour to Knowledge