Anti Microbial Resistance Profile of E. coli isolates From Tropical Free Range Chickens



common feature in these isolates, highlighting the fact that the resistance genes for
these drugs are linked on plasmids.(32) Moreover, the wide spread resistance to
cotrimoxazole may be implying the presence of class 1 integrons, which are also
important in conferring resistance to multiple anti-microbials.(33)

Norfloxacin was incorporated in many of the patterns observed in the present study
especially the predominant ones. This probably points to the fact that the E. coli
strains encountered in these free-range poultries might have originated from human
hosts where their resistances to fluoroquinolones were first selected and
subsequently disseminated to lower animals.(5) There is strong evidence that anti-
microbial use in humans has not only driven the emergence of multi-drug resistant
clones in the developing countries such as Nigeria that has resulted in an
increasingly high prevalence of multiple resistance.(8-11)

References

1. Van den Bogaard AE, Stobberingh EE. Epidemiology of resistance to
antibiotics. Links between animals and humans. International Journal of
Antimicrobial Agents. 2000;14:327-335.

2. Lester SC, del Pilar Pla M, Wang F. The carriage of Escherichia coli resistant to
anti-microbial agents by healthy children in Boston, in Caracas, Venezuela and
in Qin Pu, China. New England Journal Medicine 1990;323:285-289

3. Murray BE. Problems and Dilemmas of anti-microbial resistance.
Pharmacotherapy 1992;12:865-935.

4. Singleton P. Bacteria in biology, biotechnology and medicine, 4th Ed. John
Wiley and sons. Ltd, New York, Toronto; 1997.

5. Lipsitch M, Samore MH. Anti-microbial use and anti-microbial resistance: A
population perspective. Emerging Infectious Diseases 2002;8:347-354.

6. Halloran ME, Struchiner CJ. Study designs for dependent happenings.
Epidemiology 1991;2:331-338.

7. Donskey CJ, Chowdhry TK, Hecker MT et al. Effect of antibiotic therapy on the
density of vancomycin-resistant enteroccoci in the stool of colonized patients.
N. Engl. J. Med., 2000; 343: 1925-32.

8. Agarwa lKC, Garg RK, Panhotra BR et al. Drug resistance in salmonella
isolated at Chandigarh (India) during 1972-1978. Antonie Van Leeuwenhoek
1980;46:387-390.

9. Ling J, Chau PY, Rowe B. Salmonella serotypes and incidence of multiple-
resistant salmonellae isolated from diarrhoeal patients in Hong Kong from
1973-1982. Epidemiological of Infection 1987;99:295-306.

10. Kariuki S, Gilks C, Corkill J et al. Multi-drug resistant non-typhoid salmonellae
in Kenya. Journal of Antimicrobial Chemotherapy 1996;38:425-34.

11. Okoli IC, Okeudo NJ, Onwuchekwa CI. New trends in antibiotic resistance
among E. coli isolates from southern Nigeria. In book of abstracts for the 39th
annual national congress, Nigerian Veterinary Medical Association, 2002
October 27- 31; Sokoto, Nigeria. 2002, p. 16.

12. Levy SB. Antibiotic resistance: an ecological imbalance. In Chadwick DJ, Goode
J, eds. Antibiotic resistance. Origins, evolution, selection and spread.
Chichester: John Wiley & Sons; 1997. p. 1-14.

13. Wray C. Medical impact of anti-microbial use in food animal production.
Scenarios and risk assessment, salmonella and E coli in England and Wales.
Proceeding of the WHO Meeting on the Usage of Quinolones in Animals, Berlin.
1997. p. 45 -51.

14. Khachatourians GG. Agricultural use of antibiotics and the evolution and
transfer of antibiotic resistant bacteria. CMAJ 1998;159:1129-1136.

OJHAS Vol 4 Issue 3, 2005-3-3: Original Article. Antimicrobial resistance profile of E.coli isolates from tropical free range chickens. www.ojhas.org/issue15/2005-3-3.htm

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