129
into input to a branched model neuron is easy because the input terms look much
like currents from ion channels. On branch b the synaptic current from receptors of
type Q is given by
sb
IbQ<^, i) = 52 GQrbsQ{t)δ(x - xbs) (v⅛ - Eq) , (5.2)
where Gq is the maximal conductance, and Eq is the reversal potential of that re-
ceptor. One notable exception to this form of synaptic current is the NMDA current
because it is voltage-dependent, a fact that poses an extra problem for model reduc-
tion.
5.1.1 Reduction of the NMDA Magnesium Block Term
The NMDA receptor is governed by a magnesium block that is in the bound state
when the voltage is close to rest. When there is sufficient depolarization, Mg2+ is
unbound from the receptor and this permits a larger synaptic current to flow. Hence
the NMDA synaptic current has the form
Sb
Λ>,NMDa(^> t) — 52 GfNMDA'rbs,NMDA(t)Bb(vb)δ(x — Xbs) (vb ~ ¾IMDa) ) (5.3)
s=l
where
Bb^ ~ 1 + exp(-0.062ub)[W2+]o∕3.57
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