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54

HCN Isoform ½∕₂±std (mV) τ±std @ -94 mV (ms)

Rod∕⅛	-77 ± .78 (n=10)	52.3 ± 9.5 (n=4)
Cone Ih	-74 ± 1.1 (n=10)	50.7 ± 8.0 (n=8)
HCNl	-69	84
HCN2	-95	557
HCN3	. -77	1408
HCN4	-81	3586

Table 3.1 : Kinetic parameters for ∕⅛ and HCN isoforms. Kinetic data for both rods and
cones are similar, and comparable to parameters from the HCNl isoform. Data for HCN 1-
4 come from measurements from homogeneous expression systems (Altomare et al., 2001,
Stieber et al., 2005). The half activation voltage for HCNl is known to be ~5 mV more
hyperpolarized in in-vivo systems than in the expression system (Altomare et al., 2001),
putting it on par with measured salamander I_h.

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