Economic Evaluation of Positron Emission Tomography (PET) in Non Small Cell Lung Cancer (NSCLC), CHERE Working Paper 2007/6

Appendix 3: Summary of the studies found in the literature review
Study	Comparison	Patient group	Incremental analysis	Measure of effectiveness	Method	Effectiveness (per patient)	Cost (per patient)	Incremental cost effectiveness
NICE guidelines Surgery model (2005) UK	a) Patients go straight to thoracotomy b) Patients have a mediastinoscopy and then receive either radical radiotherapy (N2/N3) or Thoractomy (N0/1) c) Patients have a PET scan and then receive either active supportive care (M1+) OR Thoractomy (M0,N0/N1) OR Radical radiotherapy (M0, N2/N3)	Potential operable patients with normal sized lymph nodes on CT considered for surgery	Cost Utility	Quality adjusted life year (QALYs)	Decision Analysis	a) 2.846 QALYS b) 2.864 QALYS c) 2.883 QALYS	a) 6317.39 b) 7519.71 c) 6581.87	c) vs a) £7,199/QALY gained b) dominated by c)
NICE guidelines Radiotherapy model (2005) UK	a) Patients go straight to radical radiotherapy b) Patients have a PET scan and then receive either ASC (M1) or thoractomy (N0/1) or radical radiotherapy (n2/3)	Patients being considered for radical radiology (mainly enlarged nodes)	Cost Utility	Quality adjusted life year (QALYs)	Decision Analysis	b) vs a ) 4.3 QALYs	b) vs a) 40,936	b) vs a) £9,489/QALY gained

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