The equilibrium potential for given ion could be calculated by the Nernst
equation:
(84)
E
ion
RT
= —ln
FZ
[ Ion] e
[ Ion]i
where R is the gas constant, T is the temperature, F is the Faraday’s constant, Z
is the valence of the ion, [Ion]e and [Ion]i are the ion concentrations in the
extracellular and in the intracellular space.
The voltage-dependent conductances GNa(t) and GK(t) are given by
(85) GNa(t) = GNmaaxfNa(t)
(86)
GK(t)= GKmaxfK(t)
where GNmaax and GKmax are the peak or maximal sodium and potassium
conductances per unit membrane area and fNa(t) and fK(t) are each the
corresponding (instantaneous) fraction of the maximal conductance which is
actually open (or active).
Thus the equation, which describes the membrane potential as a function of all
the currents that flow across it, is
(87)
Cm^v = GNSOx fNa (t)[ ENa - V (t)] + GJm’x f< (t)[ Ek - V (t)]
+GLmaxfL(t)[EL-V(t)]
+Iinjected(t)
The values for some of the parameters are: ENa = +60 mV, GNmaax = 120 mS/cm2,
EK= -93 mV, GKmax = 36 mS/cm2, EL= -60 mV and GLmax = 0.3 mS/cm2.
KK L L
50
More intriguing information
1. AMINO ACIDS SEQUENCE ANALYSIS ON COLLAGEN2. Long-Term Capital Movements
3. The name is absent
4. The name is absent
5. Pupils’ attitudes towards art teaching in primary school: an evaluation tool
6. Can we design a market for competitive health insurance? CHERE Discussion Paper No 53
7. Evaluating the Success of the School Commodity Food Program
8. The name is absent
9. Biological Control of Giant Reed (Arundo donax): Economic Aspects
10. Solidaristic Wage Bargaining