Antidote Stocking at Hospitals in North Palestine



Table 3: The current availability of 16 selected antidotes at all hospitals of north
Palestine and comparing it to the consensus guidelines for antidotes stocking in
emergency departments in the US [15]

Antidote

Frequency
(n=11)

Poisoning Indication(s)

Presentation*

Dose (70 kg pa-
_______tient)_______

N-acetylcystine

2

Acetaminophen

200mg/ml,10 ml
_____
ampoule____

19.6 g

Snake an-
tivenin

1

Snake bites

10 ml/vial

10 vials

Calcium glu-
conate

11

Hydrogen fluoride (HF) or calcium
_________channel blocker_________

10%,10 ml ampoule

100 mEq

Sodium bicar-
bonate

11

1) Tricyclic antidepressant, 2) co-
________caine, 3) salicylates________

8.4%,50 ml vial

500 mEq

Deferoxamine

4

__________________Iron_________________

500 mg/vial

8.4 g

Digoxin specific
_____Fab_____

NA

Digoxin, digitoxin, or natural prod-
________ucts (plants, toads)________

38 mg/vial

15 vials

Dimercaprol

1

Acute arsenic, inorganic mercury,
________________lead________________

50 mg/ml,2ml am-
_______poule______

280 mg

Atropine

11

Carbamate or organophosphate in-
______________secticide______________

600 mcg/ml,1ml am-
_______poule______

75 mg

Cyanide anti-
_____
dote_____

1

Cyanide

30 mg/ml,10 ml am-
_______
poule______

1 kit

Ethanol

NA

1) Methanol, 2) ethylene glycol

5ml/ ampoule

90.7 mL ~

Fomepizole

NA

1) Methanol, 2) ethylene glycol

5mg/ml, 20ml am-
_______poule______

1.05 g

Glucagon

NA

1) β-adrenergic antagonist,
2) calcium channel blocker

1 mg/vial

50 mg

Methlene blue

3

Methemoglobinemia

10mg/ml, 10ml am-
_______poule______

140 mg

Naloxone

11

Acute opioid poisoning

10mg/ml, 10 ml am-

_______poule______

15 mg

Obidoxime

4

Organophosphate insecticide

400 mcg/ml,1ml am-
_______poule______

1 g

Pyridoxine

1

Isoniazid (INH)

100 mg/1ml, 10 ml
_____ampoule____

10 g

NA: not available

* could be available in other different presentations

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Discussion:

Antidotes are therapeutic agents
intended to modify or counteract with
the clinical effects of particular toxic
substances in the human body;
antidote availability may often be life
saving for poisoned individuals.[5]
Although their clinical importance
should not be emphasized over good
supportive care, delayed use or
unavailability of antidotes could result
in catastrophic consequences.[3,20]
For example, the outcome in patients
with severe methemoglobinemia is
poor without intravenous methylene
blue treatment [21]. In cyanide
poisoning, the lack of prompt antidote
treatment with nitrite and thiosulfate
may result in anoxic brain injury or

death.[3] Patients with severe
cholinergic syndrome from
organophosphate or carbamate
insecticide poisoning are likely to die
from respiratory failure without the
early institution of atropine.[22] Since
the timely use of antidotes is
potentially lifesaving in certain
poisonings, maintaining a sufficient
stock of antidotes is a responsibility of
any facility that provides emergency
care. If a poisoned patient requires an
antidote that is not stocked at a
particular hospital, then either the
patient must be transferred or the
antidote must be obtained from
another hospital. This is complicated
by the fact that Palestine has longer


OJHAS Vol 5 Issue 4(4) - Sawalha AF, Sweileh WM, Zyoud SH, Al-Jabi SW. Antidote Stocking at Hospitals in North Palestine




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