Supplemental Table
Table S1. Chronic lithium administration is effective against FX audiogenic seizures.
|
Strain |
Li chow duration |
AGS |
AGS observed (%) |
% nl |
av. Li level mmol/L |
t-test Li level AGS+v.- |
weight (g.) av. |
% nl chow |
t-test weight. AGS+v.- |
|
FVB-FX |
9^d. |
10/17- 7/17+ |
41 |
~45 |
20 2.2+ |
p=0.55 |
13.3- 13.5+ |
62 65 |
p=0.93 |
|
FVB-FX |
29 d. |
5/8- 3/8+ |
38 |
~41 |
28- 2.9+ |
p=0.89 |
5^2- 4.5+ |
24 22 |
p=0.36 |
|
HYB-FX |
7"d. |
9/9- 0/9+ |
0 |
1.0 (± 0.1) |
n.a. |
13.2 (± 0.4) |
n.a. | ||
|
FVBwt |
9^d. |
17/17- 0/17+ |
0 |
~33 |
1.4 (± 0.1) |
n.a. |
11.1 (± 0.3) |
55 |
n.a. |
|
HYBwt |
7"d. |
7/7- 0/7+ |
0 |
0.58 (± 0.04) |
n.a. |
16.2 (± 0.8) |
67 |
n.a. | |
|
HYBwt |
29 d. |
6/6- 0/6+ |
0 |
2.2 (± 0.1) |
n.a. |
5.4 (± 0.2) |
22 |
n.a. |
Table S1. Chronic lithium administration is effective against FX audiogenic seizures.
All lithium carbonate chow durations refer to the administration time prior to the test (d=days).
There was no normal chow wash out period. Abbreviations: “AGS” is audiogenic seizure; “nl” is
normal, and “av” is average. For numbers of mice, “-“ indicates the sub-group of treated mice
which did not have seizures; “+” indicates the sub-group of mice which did. “% nl chow AGS”
represents a comparison of the AGS levels after Li chow to those obtained with the same sex,
age, and strain of mice eating normal chow, for which our historical averages have been
approximately 92% for FVB-FX and 20% for FVB-wt (see also Figure 1). “t-test Li AGS + v. -“