The name is absent

shows the probability value for a t-test comparing the serum lithium levels of those mice having
seizures with those that did not. Statistical significance level was p = 0.5 or less. “% nl chow
weight” compares the average weight of mice fed lithium chow (under the conditions for the
given row) with comparable mice fed normal (non-lithium containing) chow. (Body weight was
used as a measure of reduced growth and body size throughout development; there was no
weight loss observed.) “t-test weight AGS + v. -“ compares the weights of those mice which
seized on the lithium diet with those that did not. “(± standard error of the mean)” is presented in
the table for lithium levels and weights, except for FVB-FX mice, for which the additional data
are as follows: 2.0 ±0.3, 2.2.±0.2, 2.8±0.2, 2.9±0.2, 13.3±0.95, 13.5±0.8, 5.2±0.5, 4.5±0.2.

Supplemental Figure Legends

Figure S1. Survival increases with body weight for nursling FX mice given repeat ip
administration of GSK3 inhibitor SB-216763.

(A) Linear regression of percentage survival of groups of 4 - 7 nursing mice given SB-216763
(10 mg/kg; ip) vs. starting body weight (“wt.”). Five of the groups tested were F1 hybrid FX
mice, three were FVB FX mice, and two were FVB wild-type mice. The wild-type mice
represent one of each pair at 100% survival (16.5g and 19.1g average weights). (B) The same
SB-216763 data plus two groups of FX FVB mice injected with 70 μl DMSO vehicle only, as
well as two groups which received 10 mg/kg MPEP + 10 mg/kg SB-216763 simultaneously.

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