A novel selective 11b-hydroxysteroid dehydrogenase type 1 inhibitor prevents human adipogenesis



11b-HSD1 is essential for human adipogenesis . I J BUJALSKA and others 307

Shafqat N, Elleby B, Svensson S, Shafqat J, Jornvall H, Abrahmsen L &
Oppermann U 2003 Comparative enzymology of 11
b -hydroxysteroid
dehydrogenase type 1 from glucocorticoid resistant (guinea pig) versus
sensitive (human) species.
Journal of Biological Chemistry 278 2030—2035.

Slavin BG, Ong JM & Kern PA 1994 Hormonal regulation of hor mone-
sensitive lipase activity and mRNA levels in isolated rat adipocytes.
Journal of
Lipid Research 35
1535-1541.

Stewart PM, Boulton A, Kumar S, Clark PM & Shackleton CH 1999 Cortisol
metabolism in human obesity: impaired cortisone
/cortisol conversion in
subjects with central adiposity.
Journal of Clinical Endocrinology and Metabolism
84 1022-1027.

Tomlinson JW, Sinha B, Bujalska I, Hewison M & Stewart PM 2002
Expression of 11
b-hydroxysteroid dehydrogenase type 1 in adipose tissue is
not increased in human obesity.
Journal of Clinical Endocrinology and
Metabolism
87 5630-5635.

Tomlinson JW, Moore JS, Clark PM, Holder G, Shakespeare L & Stewart PM
2004 Weight loss increases 11
b-hydroxysteroid dehydrogenase type 1
expression in human adipose tissue.
Journal of Clinical Endocrinology and
Metabolism
89 2711-2716.

Valsamakis G, Anwar A, Tomlinson JW, Shackleton CH, McTernan PG,
Chetty R, Wood PJ, Banerjee AK, Holder G, Barnett AH
et al. 2004
11
b-hydroxysteroid dehydrogenase type 1 activity in lean and obese males
with type 2 diabetes mellitus.
Journal of Clinical Endocrinology and Metabolism
89 4755-4761.

Walker BR, Connacher AA, Lindsay RM, Webb DJ & Edwards CR 1995
Carbenoxolone increases hepatic insulin sensitivity in man: a novel role for
11-oxosteroid reductase in enhancing glucocorticoid receptor activation.
Journal of Clinical Endocrinology and Metabolism 80 3155-3159.

Walker EA, Clark AM, Hewison M, Ride JP & Stewart PM 2001 Functional
expression, character ization, and purification of the catalytic domain of
human 11
b-hydroxysteroid dehydrogenase type 1. Journal of Biological
Chemistry
276 21343-21350.

White PC, Mune T & Agarwal AK 1997 11b-Hydroxysteroid dehydrogenase
and the syndrome of apparent mineralocorticoid excess.
Endocrine Reviews
18 135-156.

Wolf G 1999 The molecular mechanism of the stimulation of adipocyte
differentiation by a glucocorticoid.
Nutrition Reviews 57 324-326.

Wu Z, Bucher NL & Farmer SR 1996 Induction of peroxisome proliferator-
activated receptor gamma during the conversion of 3T3 fibroblasts into
adipocytes is mediated by C/EBP
b, C/EBPd, and glucocorticoids.

Molecular and Cellular Biology 16 4128-4136.

Yang S, Xu X & Bjorntorp P 1993 Effects of dexamethasone on primarily
cultured newly differentiated rat adipocytes from different adipose tissue
regions.
Obesity Research 1 99-105.

Received in final form 26 February 2008

Accepted 4 March 2008

Made available online as an Accepted Preprint
4 March 2008

www.endocrinology-journals.org


Journal of Endocrinology (2008) 197, 297-307



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