Deletion of a mycobacterial gene encoding a reductase leads to an altered cell wall containing β-oxo-mycolic acid analogues, and the accumulation of long-chain ketones related to mycolic acids



ACKNOWLEDGEMENTS

The authors would like to thank T. Hsu, J. Kriakov and W. R. Jacobs Jr. (Albert Einstein College
of Medicine, New York) for the generous gift of p0004S and phAE159, and H. Ghadbane,
University of Birmingham for helpful comments on this manuscript. This work was supported in
part by a Career Development Award to A.B. from the Medical Research Council. G.S.B.
acknowledges support from the Wellcome Trust (Ref. 076579/Z/05/Z), the Medical Research
Council, the Royal Society-Wolfson Research Merit Award and from Mr. James Bardrick.
D.E.M. was a Leverhulme Emeritus Fellow (2006-2008).

20



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