Deletion of a mycobacterial gene encoding a reductase leads to an altered cell wall containing β-oxo-mycolic acid analogues, and the accumulation of long-chain ketones related to mycolic acids



Franzblau, S.G., Witzig, R.S., McLaughlin, J.C., Torres, P., Madico, G., Hernandez, A., Degnan,
M.T., Cook, M.B., Quenzer, V.K., Ferguson, R.M.
, et al. (1998). Rapid, low-technology MIC
determination with clinical
Mycobacterium tuberculosis isolates by using the microplate Alamar
Blue assay. J. Clin. Microbiol.
36, 362-366.

Gande, R., Gibson, K.J., Brown, A.K., Krumbach, K., Dover, L.G., Sahm, H., Shioyama, S.,
Oikawa, T., Besra, G.S., and Eggeling, L. (2004). Acyl-CoA carboxylases (
accD2 and accD3),
together with a unique polyketide synthase (Cg-
pks), are key to mycolic acid biosynthesis in
Corynebacterianeae such as
Corynebacterium glutamicum and Mycobacterium tuberculosis. The
J. Biol. Chem.
279, 44847-44857.

Gao, L.Y., Laval, F., Lawson, E.H., Groger, R.K., Woodruff, A., Morisaki, J.H., Cox, J.S.,
Daffe, M., and Brown, E.J. (2003). Requirement for
kasB in Mycobacterium mycolic acid
biosynthesis, cell wall impermeability and intracellular survival: implications for therapy. Mol.
Microbiol,
49, 1547-1563.

Glickman, M.S., Cox, J.S., and Jacobs, W.R., Jr. (2000). A novel mycolic acid cyclopropane
synthetase is required for cording, persistence, and virulence of
Mycobacterium tuberculosis.
Mol. Cell
5, 717-727.

Jackson, M., Raynaud, C., Laneelle, M.A., Guilhot, C., Laurent-Winter, C., Ensergueix, D.,
Gicquel, B., and Daffe, M. (1999). Inactivation of the antigen 85C gene profoundly affects the
mycolate content and alters the permeability of the
Mycobacterium tuberculosis cell envelope.
Mol. Microbiol.
31, 1573-1587.

Kremer, L., Douglas, J.D., Baulard, A.R., Morehouse, C., Guy, M.R., Alland, D., Dover, L.G.,
Lakey, J.H., Jacobs, W.R., Jr., Brennan, P.J.
, et al. (2000). Thiolactomycin and related analogues
as novel anti-mycobacterial agents targeting KasA and KasB condensing enzymes in
Mycobacterium tuberculosis. J. Biol. Chem. 275, 16857-16864.

Lea-Smith, D.J., Pyke, J.S., Tull, D., McConville, M.J., Coppel, R.L., and Crellin, P.K. (2007).
The reductase that catalyzes mycolic motif synthesis is required for efficient attachment of
mycolic acids to arabinogalactan. J. Biol. Chem.
282, 11000-11008.

23



More intriguing information

1. Staying on the Dole
2. The Provisions on Geographical Indications in the TRIPS Agreement
3. Innovation Trajectories in Honduras’ Coffee Value Chain. Public and Private Influence on the Use of New Knowledge and Technology among Coffee Growers
4. Spatial patterns in intermunicipal Danish commuting
5. Ex post analysis of the regional impacts of major infrastructure: the Channel Tunnel 10 years on.
6. The name is absent
7. Do imputed education histories provide satisfactory results in fertility analysis in the Western German context?
8. On Social and Market Sanctions in Deterring non Compliance in Pollution Standards
9. Shifting Identities and Blurring Boundaries: The Emergence of Third Space Professionals in UK Higher Education
10. Wirkung einer Feiertagsbereinigung des Länderfinanzausgleichs: eine empirische Analyse des deutschen Finanzausgleichs
11. The name is absent
12. Financial Market Volatility and Primary Placements
13. The Advantage of Cooperatives under Asymmetric Cost Information
14. The name is absent
15. The name is absent
16. The name is absent
17. BILL 187 - THE AGRICULTURAL EMPLOYEES PROTECTION ACT: A SPECIAL REPORT
18. Exchange Rate Uncertainty and Trade Growth - A Comparison of Linear and Nonlinear (Forecasting) Models
19. The name is absent
20. Secondary stress in Brazilian Portuguese: the interplay between production and perception studies