Deletion of a mycobacterial gene encoding a reductase leads to an altered cell wall containing β-oxo-mycolic acid analogues, and the accumulation of long-chain ketones related to mycolic acids

Minnikin, D.E. and Polgar, N. (1966). Stereochemical studies on the mycolic acids. Chem.

Comm. 648-649.

Minnikin, D.E., Minnikin, S.M. and Goodfellow, M. (1982). The oxygenated mycolic acids of
Mycobacterium fortuitum, M. farcinogenes and M. senegalense. Biochim. Biophys. Acta 712,
616-620.

Parish, T., Roberts, G., Laval, F., Schaeffer, M., Daffe, M., and Duncan, K. (2007). Functional
complementation of the essential gene fabG1 of Mycobacterium tuberculosis by Mycobacterium
smegmatis fabG but not Escherichia coli fabG. J. Bacteriol. 189, 3721-3728.

Peterson, D.O., and Bloch, K. (1977). Mycobacterium smegmatis fatty acid synthetase. Long
chain transacylase chain length specificity. J. Biol. Chem. 252, 5735-5739.

Portevin, D., De Sousa-D'Auria, C., Houssin, C., Grimaldi, C., Chami, M., Daffe, M., and
Guilhot, C. (2004). A polyketide synthase catalyzes the last condensation step of mycolic acid
biosynthesis in mycobacteria and related organisms. Proc. Natl. Acad. Sci. USA 101, 314-319.

Pudles, J., and Lederer, E. (1954). Isolation and chemical constitution of coryno-mycolenic acid
and of two ketones from lipids of the diphtheria bacillus. Bull. Soc. Chim. Biol. 36, 759-777.

Rao, V., Gao, F., Chen, B., Jacobs Jr., W.R., and Glickman, M.S. (2006). Trans-
cyclopropanation of mycolic acids on trehalose dimycolate supresses Mycobacterium
tuberculosis-induced inflammation and virulence. J. Clin. Invest. 116, 1660-1667.

Sacco, E., Covarrubias, A.S., O'Hare, H.M., Carroll, P., Eynard, N., Jones, T.A., Parish, T.,
Daffe, M., Backbro, K., and Quemard, A. (2007). The missing piece of the type II fatty acid
synthase system from Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. USA 104, 14628-
14633.

Sassetti, C.M., Boyd, D.H., and Rubin, E.J. (2003). Genes required for mycobacterial growth
defined by high density mutagenesis. Mol. Microbiol. 48, 77-84.

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