The name is absent

Significant decreases in symptom severity were identified on 4 of the 13 items of the RSI domain
(interest in other children, response to children’s approaches, use of other’s body to communicate,
inappropriate facial expression). A significant decrease was also identified on 3 of the 7 items of the
NVC domain (gestures, nodding and social play). There were no significant changes in the VC domain.
A significant decrease was identified in one of the 7 items of the repetitive behaviour domain
(repetitive use of objects).

T1 variables associated with ADI-R scores at follow-up

Table 4 describes Pearson correlation coefficients between the following T1 variables: ADI-R score,
IQ, ADI-R overall language level (according to Q19 of the ADI-R), VABS communication, daily
living and socialization standard scores and outcome on ADI-R total and domain scores at FU.
Correlation coefficients indicated that communication (VABS communication score and overall level
of language), socialization skills, IQ and symptom severity at T1 all demonstrate a strong association
with outcome on the ADI-R at FU.

(Insert Table 4 about here)

In order to examine the extent of change shown by individual children, ADI-R change (FU-T1) scores
at domain and total score level were divided into quartiles. Participants whose change scores were ≥
75^th or ≤ 25^th quartile were considered to have made the most and least progress respectively. T1
receptive and expressive language skills were significantly better in those who made the most progress
between T1 and FU. No other significant differences were identified (See Table 5).

(Table 5 about here)

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