The name is absent



19


Eigenvalues of A for standard Hodgkin-Huxley kinetics
0.4r                                             ×

Frequency response of isopotential HH cell


0.3
0.2
0.1
  0 ×                                     ×

-0.1
-0.2
-0.3
—0.4-------------'--------------'--------------'-------------'----------x

-5      -4      -3      -2      -1       0

Reλ

Figure 2.4: Left: Eigenvalues of the 4-by-4 matrix A given in (2.13). Right: Frequency
response of the active (solid) and quasi-active (dashed) models using standard HH kinetics.

evaluated numerically via a high-order quadrature scheme such as Clcnshaw-Curtis
quadrature, as described in (Trefethen, 2007).

Not only does the eigenvalue decomposition yield an analytic solution, but also the
eigenvalues of
A will tell us whether resonant frequencies exist and, if so, where in the
spectrum to look for them. Recall that if A is an eigenvalue of
A and if Imag(A) ≠ 0,
then the resonant frequency is in the neighborhood of

2πlmag(λ)
Cl7t∙ —    `                   .

1000

where the 1000 in the denominator is to convert from milliseconds to seconds (i.e.,
from mHz to Hz). If Real(A) — 0 then
ωr is exactly the resonant frequency. However,
the quasi-active system is dissipative, meaning that it is possible that some eigenvalues
have Real(A) ≠ 0, and thus the above equation is only an approximation to
ωr.



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