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98



Figure 4.4: Sl through S4. Panels (a) through (d) show the average number of
patients (Ni) and early stopping probabilities (pi) under scenarios Sl through S4.
Both summaries are with respect to repeat experimentation. Summaries are arranged
by the simulation truth pi, shown on the horizontal axis. In each panel, the upper
part shows the average number of patients Ni that enter into the study for each
arm. The lower part shows the early stopping probability (pi). The stars (“*”) show
summaries under the NEPPM. The circles (“o”) show summaries for the HLRM. The
character size is proportional to Ni, the maximum sample size for each subtype.




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