work has shown that this type of charge regulation plays an important role in biological
macroion-lipid interactions, especially in protein-lipid, peptide-lipid and DNA-Iipid
interactions [72-77]. In particular, DNA-Cationic lipid complexes have shown potential
for therapeutic applications such as transporting DNA into cells and non-viral gene
therapy [58-62]. Our analysis offers a means of gaining further understanding of this
important phenomenon at the nanometer scale.
50
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