SIZE OF HIPPOCAMPAL PYRAMIDAL NEURONS IN SCHIZOPHRENIA
Gruzelier, J., Seymour, K.,Wilson, L., et al (1988)
IImpairments on neuropsychologiic tests of
temporohippocampal and frontohippocampal functions
and word fluency iin remittiing schizophrenia and
affective disorders. Archives of General Psychiatry, 45,
623^629.
Gundersen, H. J. & Jensen, E. B. (1987) The eff iiciency
of systematiic sampling in stereology and its prediction.
Journal of Microscopy, 147, 229^263.
Gur, R. E., Cowell, P., Turetsky, B. I., et al (1998) A
follow-up magnetic resonance iimaging study of
schizophrenia. Relatiionship of neuroanatomical changes
to clinical and neurobehaviorall measures. Archives of
General Psychiatry, 55, 145^152.
Harrison, P. J. (1999) The neuropathollogy of
schizophrenia: a critical review of the data and their
iinterpretation. Brain, 122, 593^624.
Heckers, S., Heinsen, H., Heinsen, Y. C., et al (1990)
Liimbic structures and lateral ventricle in schizophrenia.
A quantitative postmortem study. Archives of General
Psychiatry, 47, 1016^1022.
__ , __ , Geiger, B., et al (19 91) Hippocampall neuron
number iin schiizophreniia. A stereologicall study. Archives
of General Psychiatry, 48, 1002^1008.
Highley, J. R., McDonald, B., Walker, M. A., et al
(1999) Schizophrenia and temporal llobe asymmetry. A
post-mortem stereologicall study of tissue volume. British
Journal of Psychiatry, 175, 127^1134.
Howard, C.V. & Reed, M. G. (1998) Unbiased
Stereology. Three-dimensional Measurement in Microscopy.
New York: Springer.
Jeste, D.V. & Lohr, J. B. (1989) Hippocampal pathollogiic
findings in schiizophrenia. A morphometriic study.
Archives of General Psychiatry, 46, 1019^11024.
McDonald, B., Highley, J. R., Walker, M. A., et al
(2000) Anomalous asymmetry of fusiform and
parahiippocampall gyrus gray matter in schizophreniia: a
postmortem study. American Journal of Psychiatry, 157,
40^47.
Nelson, M. D., Saykin, A. J., Flashman, L. A., et al
(1998) Hippocampal volume reduction in schizophreniia
as assessed by magnetiic resonance iimagiing: a meta-
analytic study. Archives of General Psychiatry, 55,
433^440.
Saykin, A. J., Gur, R. C., Gur, R. E., et al (1991)
Neuropsychological function in schizophrenia. Sellectiive
CLINICAL IMPLICATIONS
& Memory impairments in schizophrenia cannot be attributed to alterations in size
ofhippocampal neurons.
& Reduction in size of the hippocampus in schizophrenia is not explained by reduced
hippocampal neuron size.
LIMITATIONS
& The sample sizes are relatively small.
& There is the possibility of a type II error (failure to detect a true difference
between the brains of people with and without schizophrenia).
& The hippocampus was analysed as a whole, so changes in a part, such as the
anterior half, might have been missed.
J. R. HIGHLEY, MB DPhiil, M. A.WALKER, B. McDONALD, FRCPath, Department of Clliniical Neurology;
T. J. CROW, MB PhD, Department of Psychiatry; M. M. ESIRI, DM FRCPath, Department of Clinical Neurollogy,
Universiity of Oxford, UK
Correspondence: Professor M. M. Esiri, Neuropathology Department, Radcliffe Infirmary, Oxford OX2
6 HE, UK. Tell: 01865 224403 ; fax: 01865 224508 ; e-mail: margaret. esiri @cllneuro.ox.ac. uk
(First received 24 January 2003, final revision 2 June 2003, accepted 4 June 2003)
impairment in memory and llearning. Archives of General
Psychiatry, 48, 618^624.
Walker, M. A., Highley, J. R., Esiri, M. M., et al (2002)
Estiimated neuronall populations and volumes of the
hippocampus and its subfiields in schizophreniia. American
Journal of Psychiatry, 159, 8211^828.
West, M.J. (1999) Stereological methods for estimatiing
the totall number of neurons and synapses: iissues of
preciisiion and bias. Trends in Neurosciences, 22, 51^611.
__ & Gundersen, H. J. (1990) Unbiased stereological
estiimatiion of the number of neurons iin the human
hippocampus. Journal of Com parative Neurology, 296,
1^22.
Zaidel, D.W., Esiri, M. M. & Harrison, P. J. (1997) Siize,
shape, and orientation of neurons in the left and riight
hippocampus: investigation of normall asymmetriies and
alterations in schizophrenia. American Journal of
Psychiatry, 154, 812^818.
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