The name is absent



SIZE OF HIPPOCAMPAL PYRAMIDAL NEURONS IN SCHIZOPHRENIA

Gruzelier, J., Seymour, K.,Wilson, L., et al (1988)
IImpairments on neuropsychologiic tests of
te
mporohippocampal and frontohippocampal functions
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uantitative postmortem study. Archives of General
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__ , __ , Geiger, B., et al (19 91) Hippocampall neuron
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CLINICAL IMPLICATIONS

& Memory impairments in schizophrenia cannot be attributed to alterations in size
of
hippocampal neurons.

& Reduction in size of the hippocampus in schizophrenia is not explained by reduced
hi
ppocampal neuron size.

LIMITATIONS

& The sample sizes are relatively small.

& There is the possibility of a type II error (failure to detect a true difference
be
tween the brains of people with and without schizophrenia).

& The hippocampus was analysed as a whole, so changes in a part, such as the
anterior half, might have been missed.


J. R. HIGHLEY, MB DPhiil, M. A.WALKER, B. McDONALD, FRCPath, Department of Clliniical Neurology;

T. J. CROW, MB PhD, Department of Psychiatry; M. M. ESIRI, DM FRCPath, Department of Clinical Neurollogy,
Universiity of Oxford, UK

Correspondence: Professor M. M. Esiri, Neuropathology Department, Radcliffe Infirmary, Oxford OX2
6 HE, UK. Tell: 01865 224403 ; fax: 01865 224508 ; e-mail: margaret. esiri @cllneuro.ox.ac. uk

(First received 24 January 2003, final revision 2 June 2003, accepted 4 June 2003)


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__ Gundersen, H. J. (1990) Unbiased stereological
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417




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