SIZE OF HIPPOCAMPAL PYRAMIDAL NEURONS IN SCHIZOPHRENIA
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CLINICAL IMPLICATIONS
& Memory impairments in schizophrenia cannot be attributed to alterations in size
ofhippocampal neurons.
& Reduction in size of the hippocampus in schizophrenia is not explained by reduced
hippocampal neuron size.
LIMITATIONS
& The sample sizes are relatively small.
& There is the possibility of a type II error (failure to detect a true difference
between the brains of people with and without schizophrenia).
& The hippocampus was analysed as a whole, so changes in a part, such as the
anterior half, might have been missed.
J. R. HIGHLEY, MB DPhiil, M. A.WALKER, B. McDONALD, FRCPath, Department of Clliniical Neurology;
T. J. CROW, MB PhD, Department of Psychiatry; M. M. ESIRI, DM FRCPath, Department of Clinical Neurollogy,
Universiity of Oxford, UK
Correspondence: Professor M. M. Esiri, Neuropathology Department, Radcliffe Infirmary, Oxford OX2
6 HE, UK. Tell: 01865 224403 ; fax: 01865 224508 ; e-mail: margaret. esiri @cllneuro.ox.ac. uk
(First received 24 January 2003, final revision 2 June 2003, accepted 4 June 2003)
impairment in memory and llearning. Archives of General
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417
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