Synthesis and biological activity of α-galactosyl ceramide KRN7000 and galactosyl (α1→2) galactosyl ceramide

by University of Birmingham Research Archive, E-prints Repository

PubMed

Central Bioorganic & Medicinal Chemistry

Letters

Published as: BioorgMed Chem Lett. 2009 August 01; 19(15): 4288-4291.

Synthesis and biological activity of α-galactosyl ceramide

KRN7000 and galactosyl (α1→2) galactosyl ceramide

Natacha Veerapen^a, Manfred Brigl^b, Salil Garg^b, Vincenzo Cerundolo^c, Liam R. Cox^d,
Michael B. Brenner^b, and Gurdyal S. Besra^a,«

Natacha Veerapen: ; Manfred Brigl: ; Salil Garg: ; Vincenzo Cerundolo: ; Liam R. Cox: ; Michael B. Brenner: ; Gurdyal S.
Besra: [email protected]

^aSchool of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.

^bDivision of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Harvard

Medical School, 1 Jimmy Fund Way, Boston, MA 02115, USA.

^cTumor Immunology Group, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital,
Headington, Oxford OX1 3QT, UK.

^dSchool of Chemistry, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.

Graphical abstract

The synthesis and biological activity of α-galactosyl ceramide (α-GalCer) and Gal(α1→2)GalCer is
reported.

© 2009 Elsevier Ltd.

This document may be redistributed and reused, subject to certain conditions.

«Corresponding author. [email protected].

This document was posted here by permission of the publisher. At the time of deposit, it included all changes made during peer review,
copyediting, and publishing. The U.S. National Library of Medicine is responsible for all links within the document and for incorporating
any publisher-supplied amendments or retractions issued subsequently. The published journal article, guaranteed to be such by Elsevier,
is available for free, on ScienceDirect.

1   2   3   4   >>

More intriguing information