Synthesis and biological activity of α-galactosyl ceramide KRN7000 and galactosyl (α1→2) galactosyl ceramide

by University of Birmingham Research Archive, E-prints Repository

PubMed

Central Bioorganic & Medicinal Chemistry

Letters

Published as: BioorgMed Chem Lett. 2009 August 01; 19(15): 4288-4291.

Synthesis and biological activity of α-galactosyl ceramide

KRN7000 and galactosyl (α1→2) galactosyl ceramide

Natacha Veerapen^a, Manfred Brigl^b, Salil Garg^b, Vincenzo Cerundolo^c, Liam R. Cox^d,
Michael B. Brenner^b, and Gurdyal S. Besra^a,«

Natacha Veerapen: ; Manfred Brigl: ; Salil Garg: ; Vincenzo Cerundolo: ; Liam R. Cox: ; Michael B. Brenner: ; Gurdyal S.
Besra: g.besra@bham.ac.uk

^aSchool of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.

^bDivision of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Harvard

Medical School, 1 Jimmy Fund Way, Boston, MA 02115, USA.

^cTumor Immunology Group, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital,
Headington, Oxford OX1 3QT, UK.

^dSchool of Chemistry, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.

Graphical abstract

The synthesis and biological activity of α-galactosyl ceramide (α-GalCer) and Gal(α1→2)GalCer is
reported.

© 2009 Elsevier Ltd.

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«Corresponding author. g.besra@bham.ac.uk.

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