Synthesis and biological activity of α-galactosyl ceramide KRN7000 and galactosyl (α1→2) galactosyl ceramide



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Central Bioorganic & Medicinal Chemistry

Letters

Published as: BioorgMed Chem Lett. 2009 August 01; 19(15): 4288-4291.

Synthesis and biological activity of α-galactosyl ceramide

KRN7000 and galactosyl (α1→2) galactosyl ceramide

Natacha Veerapena, Manfred Briglb, Salil Gargb, Vincenzo Cerundoloc, Liam R. Coxd,
Michael B. Brennerb, and Gurdyal S. Besraa,«

Natacha Veerapen: ; Manfred Brigl: ; Salil Garg: ; Vincenzo Cerundolo: ; Liam R. Cox: ; Michael B. Brenner: ; Gurdyal S.
Besra:
[email protected]

aSchool of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.

bDivision of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Harvard

Medical School, 1 Jimmy Fund Way, Boston, MA 02115, USA.

cTumor Immunology Group, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital,
Headington, Oxford OX1 3QT, UK.

dSchool of Chemistry, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.

Graphical abstract

The synthesis and biological activity of α-galactosyl ceramide (α-GalCer) and Gal(α1→2)GalCer is
reported.

© 2009 Elsevier Ltd.

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«Corresponding author. [email protected].

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