144
Table B.3: Channel model and kinetics that allow weakly excitable dendrites. For G(x},
x is measured in μm from the soma. The model for ⅛a is divided into two components,
proximal and distal, which are denoted 1кА(ргох) and lKA(dist), respectively. Some of the
gating variables in this model have time constants τ that depend on temperature T via
a so-called Qw factor. The temperature is set to T = 35oC to match the value used in
(Migliore et al., 1999).
Gating Var.
|
m |
0.4(υ+30) O124(υ + 3O) 1—e×p(-(v-t-30)∕7.2) exp{(υ+30)∕7.2)-ɪ |
|
h |
0.03(υ + 45) 0.01(υ-f-45) 1— exp(- (υ÷45)∕1.5) exp((υ+45)∕l .5) -1 exp(0.45(∙υ -f- 60)) exp(0.09(υ + 60)) |
|
nDR |
exp(-0.11(υ — 13)) exp(-0.08(∙u — 13)) exp(-0.038(1.5 + 1+exp⅛0∕5> ))( ^ - ɪl) exp(-0.038(0.825 + 1+cxp^+40∕5) ))<» - ɪɪ) exp(-0.038(1.8 + 1+exp(i+40∕5⅛ ))(■> + ɪ) exp(-0.038(0.7 + 1+-i⅛ ))(v + ɪ) exp(0.11(v + 5β)) |
|
Ionic Current |
Gating Variables |
G(x) (mS∕cm2) |
E (mV) | |||
|
ʃleak |
0.3 |
-65 | ||||
|
INa |
m3, h, i |
32 |
55 | |||
|
Udr |
10 |
-90 | ||||
|
^A(pτt>χ∙) |
Uprox1 Iprox |
∫48(1 + I0 |
x∕100) |
x ≤ X > |
IOO μm 100 μm |
-90 |
|
ʃʌʌ(dɪst) |
Udist1 Idist |
ʃθ (48(1 + |
a√100) |
x ≤ x > |
100 μm 100 μm |
-90 |
B
|
Gating Var. |
T |
Qio factor | |
|
m |
0.5 |
a |
2(T-24)∕I0 |
|
h |
0.5 |
____________1____________ |
2(T-24)∕1O |
|
α+∕3 |
l+exp((∙υ+50)∕4) | ||
|
3×104ff |
l+0.5exp((υ÷58)∕2) | ||
|
l+α |
l+exp((υ÷58)∕2) | ||
|
«DR |
ou∕j !+ɑ |
1 | |
|
Ti |
4/3 |
1 |
5(T-24)∕10 |
|
, l,prox |
l + cι 'j∙6 ɪ l÷exp(0.2-υ∕22) |
]ʌɑ T+α | |
|
7⅛ist |
2/3 |
1 |
5(T-24)∕10 |
|
^dɪst |
υ∙^ ɪ l÷exp(0.2-v∕22) |