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32


Figure 3.3 : Nonstationary Fluctuation Analysis of HCN currents (A) Five traces from an
ensemble, and (B), variance and mean computed from the ensemble. (Cl), In the rod, cell
attached patches gave an estimate of 663 ± 71 fS, with N=155 ± 42 channels in the patch
(std., n=3, two cells). (C2) Whole-cell patches estimated the conductance to be 766 ± 242
fS, with N=2214 ± 986 channels (std., n=6). (D) In the cone, cell attached patches yielded
an estimated conductance of 526 fS with 183 channels (n=l) present per patch. Estimates
were made from the coefficients of equation 2.4




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