The name is absent



Autism prodrome 85 of 89

Table 2 (continued)

Prospective screening studies

Reference

Age

(Months)

Study design

Administration

Key items/content

Instrument parameters

Robins et al.

(2001);

Kleinman et al.

(2008)_________

M-

CHAT

24m

Combined high-risk: early
intervention referrals (
n =
484) and population

screening (n = 3,309)_________

Parent questionnaire

Most discriminating items: joint

attention behaviors and social

relatedness

Positive predictive value = 36%
(1-stage); Positive predictive
value = 74% (2-stage)

Wetherby et al.

(2004, 2008)

Ict

9-24m

Population screening (n =
5,385); multiple stage follow-
ups________________________

Parent questionnaire

Early social communication

behaviors; emotional response

Positive and negative predictive
value at or higher than 70% for
all age groups except 6 to 8m

Reznik et al.

(2007); Watson

et al. (2007)

^^FYI

12m

Pilot population study (n =
1,496)

Parent questionnaire

Full range of possible early
autism abnormal signs

Follow-up studies not yet

conducted

CHAT (Checklist for Autism in Toddlers); ESAT (Early Screening of Autistic Traits); M-CHAT (Modified- Checklist for Autism in Toddlers); ITC (Infant

Toddler Checklist); FYI (First Year Inventory)



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