The name is absent



Autism prodrome 86 of 89

Table 3

High risk sibling studies

Reference

N

(SIBS-A)

Age

(Months)

Comparison
group

Findings

Zwaigenbaum et al.

(2005)

65

6-24m

TD n = 23

Temperament characteristics (decreased activity) at 6m and behavioral markers (e.g., orienting to
name, social smiling) and language delays at 12m - predicted later ASD at 24m

Mitchell et al. (2006)

97

12-24m

TD n = 49

Siblings with ASD at 24m had more delays in gestural communication (i.e., giving, pointing, and

nodding head) at 12m

Bryson et al. (2007)

9

6-36m

Siblings with ASD at 36m showed early impaired social-communicative development (e.g., lack
of interest in others), behavioral markers (e.g., visual fixation, repetitive behaviors), distinct
temperament profile (e.g., intolerance of intrusions, dysregulated state) - associated with the
emergence of autism. Signs of autism emerged earlier (12m) in siblings with a decrease in IQ

Loh et al. (2007)

17

6-36m

TD n =15

"Hands to ears" posture at 18m was more frequent in the high risk group compared to the controls.
Siblings with a later ASD diagnoses "arm waved" more frequently at 12m and 18m. The ASD and
control groups had considerable overlap in their repertoires of stereotyped behaviors______________



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