33
Table 2.1: Toxicity frequency for randomized eligible patients by study arms. In the
placebo (Isotretinoin) group, 171 (427) out of 577 (589) patients exhibited some type
of toxicity. In bold the proportion of patients in the study arm belonging to the cell.
Placebo
|
Toxic effect |
No Tox |
Gl |
G2 |
G3 |
G4 |
|
Abnormal vision |
565(0.979) |
9(0.016) |
0(0) |
2(0.003) |
1(0.002) |
|
Arthralgia |
548(0.95) |
19(0.033) |
10(0.017) |
0(0) |
- |
|
Cheilitis |
493(0.854) |
76(0.132) |
8(0.014) |
0(0) |
- |
|
Conjunctivitis |
530(0.919) |
43(0.075) |
3(0.005) |
1(0.002) |
- |
|
Fatigue |
558(0.967) |
12(0.021) |
5(0.009) |
2(0.003) |
- |
|
Headache |
554(0.96) |
16(0.028) |
3(0.005) |
4(0.007) |
- |
|
Hyper-triglyceride |
551(0.955) |
22(0.038) |
4(0.007) |
0(0) |
- |
|
Isotretinoin | |||||
|
Abnormal vision |
579(0.983) |
8(0.014) |
1(0.002) |
1(0.002) |
0(0) |
|
Arthralgia |
544(0.924) |
30(0.051) |
10(0.017) |
5(0.008) |
- |
|
Cheilitis |
212(0.36) |
245(0.416) |
122(0.207) |
10(0.017) |
- |
|
Conjunctivitis |
449(0.762) |
98(0.166) |
31(0.053) |
11(0.019) |
- |
|
Fatigue |
572(0.971) |
14(0.024) |
3(0.005) |
0(0) |
- |
|
Headache |
580(0.985) |
9(0.015) |
0(0) |
0(0) |
- |
|
Hyper-triglyceride |
514(0.873) |
64(0.109) |
10(0.017) |
1(0.002) |
- |
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