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128

Variables and Constants

Φ

Number of photoisomerizations

R

Number of activated rhodopsin molecules

E

Number of activated PDE molecules

cG

cGMP concentration in outer seg. (μM)

c

Calcium concentration in outer seg. (μM)

Cb

Buffered calcium concentration in outer seg. (μM)

cGctark ~ 2 μM.

Dark cGMP level

ncG = 2.201

CNG channel activation Hill coeff.

Tr = 0.416 S

Rhodopsin deactivation time const.

υrp = 1734.72 s^1

Photopigment activation rate

te = 1.195 s

PDE inactivation time const.

Amax = 4.461 μM∕s

Maximum cGMP synthesis rate

Kca = 0.219 μM

Half-activation level of guanylate cyclase by Ca

nca = 2.855

Ca activated guanylate cyclase Hill coeff.

βdaτk = 0.136 S-ɪ

cGMP hydrolysis rate in darkness

[3E = 1.68 X 10^5 s“ 1

PDE dependent cGMP hydrolysis rate

b = 0.780 μMs-1pA~1

Photocurrent to Ca flux

Jd = 72.296 pA

Photocurrent model dark current

7c = 99.67 s-1

Ca exchanger extrusion rate

Cmin = 0.005 μM

Minimum outer segment Ca level

kl = 0.166 μM^1s'1

Ca buffer binding rate

et = 394.58 μM

Total Ca buffer concentration

k2 = 2.350 s’1

Ca buffer unbinding rate



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