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130


Ca-current kinetics

ʃɪæ - '∏rl'ca'lca

'm,ca — ɑmeɑ(ɪ - ^,ca) ~ βmca^ca
amca
= 100exp((w + 10)/(2 ∙ 6))
βmca = 100exp(-(v + 10)/(2 ∙ 6))

hea = ɑftea(ɪ - ^ca) - βhcahca
ahca
= 0.5exp((-υ- 11)/(2• 9))
βhca = 0.5exp(-(w - 11)/(2 • 9))


Gating with 1 activation and 1 inactivation particle


Activation particle


Inactivation particle


Inner segment Ca buffer system

Cis ~ Rin Rout


'ca (ʃeɪ^fυkcz)
0


otherwise


Variables Constants

Cis

Fc = 96500 C∕mol

V = 2000 μm3

fυ = 1 × 10~15 L∕∕≡3

kc = 1 × IO6 pC∕μC

z-2

Cmin ~ 0.05 pNl

τcai = 20 × IO-3 s


Inner seg calcium cone, in μM

Faraday constant

Volume of the inner segment
Convert μm3 to L
Conversion from pC to μC
Ca valence

Minimum inner seg. Ca concentration
Calcium extrusion time const.



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