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Ca-current kinetics
ʃɪæ - '∏rl'ca'lca
'm,ca — ɑmeɑ(ɪ - ^,ca) ~ βmca^ca
amca = 100exp((w + 10)/(2 ∙ 6))
βmca = 100exp(-(v + 10)/(2 ∙ 6))
hea = ɑftea(ɪ - ^ca) - βhcahca
ahca = 0.5exp((-υ- 11)/(2• 9))
βhca = 0.5exp(-(w - 11)/(2 • 9))
Gating with 1 activation and 1 inactivation particle
Activation particle
Inactivation particle
Inner segment Ca buffer system
Cis ~ Rin Rout
'∣ca∣ (ʃeɪ^fυkcz)
0
otherwise
Variables Constants
Cis
Fc = 96500 C∕mol
V = 2000 μm3
fυ = 1 × 10~15 L∕∕≡3
kc = 1 × IO6 pC∕μC
z-2
Cmin ~ 0.05 pNl
τcai = 20 × IO-3 s
Inner seg calcium cone, in μM
Faraday constant
Volume of the inner segment
Convert μm3 to L
Conversion from pC to μC
Ca valence
Minimum inner seg. Ca concentration
Calcium extrusion time const.